2018

  • Young Kim, Zhe Zhang, Jae-Hyuck Shim, Tae Sup Lee, and Ching-Hsuan Tung. A cell surface clicked navigation system to direct specific bone targeting. Bioorganic med. Chem. 26(3):758. 2018
  • Ren Xu, Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin, Jung-Min Kim, Shawn Debnath, Gang Ji, Mathias P. Bostrom, Xu Yang, Han Dong, Pouneh Kermani, Sarfaraz Lalani, Na Li, Yifang Liu, Michael G. Poulos, Amanda Wach, Yi Zhang, Kazuki Inoue, Annarita Di Lorenzo, Baohong Zhao, Jason M. Butler, Jae-Hyuck Shim, Lauire H. Glimcher, Matthew B. Greenblatt. Targeting skeletal endothelium to ameliorate bone loss. Nat. Med. May 21, 2018
  • Shawn Debnath,Alisha Yallowitz, Jason McComick, Sarfaraz Lalani, Tuo Zhang, Ren Xu, Yifang Liu, Yeon-Suk Yang, Jae-Hyuck Shim, Meera Hameed, John H. Healey, Dan Avi Landau, Matthew B. Greenblatt. Discovery of a periosteal stem cell mediating intramembranous bone formation and fracture healing. Nature. In press

 

2017

  • Stanley Adoro, Kwang Hwan Park, Sarah E Bettigole, Raphael Lis, Hee Rae Shin, Heewon Seo, Ju Han Kim, Klaus-Peter Knobeloch, Jae-Hyuck Shim*, and Laurie H. Glimcher. Post-translational control of T cell development by the ESCRT protein CHMP5. Nat. Immunol. 18(7), 780-790, 2017 *(Co-corresponding authorship).
  • Ren Xu, Chao Zhang, Dong Yeon Shin, Jung-Min Kim, Sarfaraz Lalani, Na Li, Yeon-Suk Yang, Yifang Liu, Mark Eiseman, Roger J. Davis, Jae-Hyuck Shim* and Matthew B. Greenblatt.  c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo. J. Bone. Miner. Res. 32(9), 1811-1815, 2017 *(Co-corresponding authorship).
  • Jae-Hyuck Shim, Zheni Stavre, Ellen Gravallese. Bone loss in Rheumatoid arthritis: Basic mechanisms and Clinical implications. Calcif. Tissue Int. Dec. 4th, 2017 

 

2016

  • Matthew B. Greenblatt, Dong Yeon Shin, Hwanhee Oh, Ki-young Lee, Bo Zhai, Steven P. Gygi, Sutada Lotinun, Roland Baron, Dou Liu, Bing Su, Laurie H. Glimcher, and Jae-Hyuck Shim. MEKK2 mediates an alternative pathway for activation of β-catenin that promotes bone formation. Proc. Natl. Acad. Sci, USA. 113 (9):E1226-35, 2016.
  • Yoon Min, Sae Mi Wi, Jung-Ah Kang, Taewoo Yang, Chul-Seung Park, Sung-Gyoo Park, Sungkwon Chung, Jae-Hyuck Shim, Eunyoung Chun, and Ki-Young Lee. Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6. Cell Death Dis. 7(7):e2313, 2016.
  • Michael G. Poulos, Pradeep Ramalingam, Michael C. Gutkin, Michael Ginsberg, Shahin Rafii, Jan Kitajewski, Matthew B. Greenblatt, Jae-Hyuck Shim, and Jason M. Butler. Endothelial-specific inhibition of NF-κB enhances functional hematopoiesis. Nat. Commun. 7:13829, 2016

2015

  • Paraskevi- Rea Oikonomidou, Casu Carla, Zhiwei Yang, Bart Crielaard, Jae-Hyuck Shim, Stefano Rivella, Maria G Vogiatzi. Polycythemia is associated with bone loss and reduced osteoblast activity in mice. Osteoporos Int. Dec, 2015.
  • Gyuyoung Moon, Juhong Kim, Yoon Min, Sae Mi Wi, Jae-Hyuck Shim, Eunyoung Chun, and Ki-Young Lee. Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1-TAB2 complex in TLR4 signaling. Cell Signal, 27(12): 2524-33.
  • Daniel S Oh, Alia Koch, Sidney Eisig, Sahng Gyoon Kim, Yoon Hyuck Kim, Do-Gyoon Kim, and Jae-Hyuck Shim. Distinctive capillary action by micro-channels in bone-like templates can enhance recruitment of cells for restoration of large bony defect. J Vis Exp, Sep 11 (103). 2015
  • Matthew B. Greenblatt, Kwang Hwan Park, Hwanhee Oh, Jung-Min Kim, Dong Yeon Shin, Jae Myun Lee, Jin Woo Lee, Anju Singh, Ki-young Lee, Dorothy Hu, Changchun Xiao, Julia F. Charles, Josef M. Penninger, Sutada Lotinun, Roland Baron, Sankar Ghosh, and Jae-Hyuck Shim. CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. J. Exp. Med.,212(8):1283-301, 2015.
  • Sae Mi Wi, Jeongho Park, Jae-Hyuck Shim, Eunyoung Chun, and Ki-Young Lee. Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling. Mol. Biol. Cell, 26 (1):151-160, 2015.
  • Matthew B. Greenblatt, Jung-Min Kim, Hwanhee Oh, Kwang Hwan Park, Min-Kyung Choo, Yasuyo Sano, Coralee E. Tye, Ziedonis Skobe, Roger J. Davis, Jin Mo Park, Marianna Bei, Laurie H. Glimcher and Jae-Hyuck Shim. p38α MAPK Is Required for Tooth Morphogenesis and Enamel Secretion. J. Biol. Chem., 290:284-295, 2015.

2014

  • So Yong Kim, Kyung-Hwa Baik, Kwan-Hyuck Baek, Kyong-Hwa Chah, Kyung Ah Kim, Gyuyoung Moon, Eunyu Jung, Seong-Tae Kim, Jae-Hyuck Shim, Matthew B. Greenblatt, Eunyoung Chun and Ki-Young Lee. S6K1 Negatively Regulates TAK1 Activity in the Toll-Like Receptor Signaling Pathway. Mol. Cell Biol., 34 (3):510-521, 2014.
  • Sae Mi Wi, Gyuyoung Moon, Juhong Kim, Seong-Tae Kim, Jae-Hyuck Shim, Eunyoung Chun, and Ki-Young Lee. TAK1-ECSIT-TRAF6 Complex Plays a Key Role in the TLR4 Signal to Activate NF-κB. J. Biol. Chem., 289:35205-35214, 2014.

2013

  • So Yong Kim, Sookyung Jeong, Kyong-Hwa Chah, Eunyu Jung, Kwan-Hyuck Baek, Seong-Tae Kim, Jae-Hyuck Shim, Eunyoung Chun, and Ki-Young Lee. Salt-inducible kinase 1 and 3 negatively regulate toll-like receptor 4 -mediated signal. Mol Endocrinol, September, 2013.
  • Kwang Hwan Park, Boryung Park, Dong Suk Yoon, Seung-Hyun Kwon, Dong Min Shin, Jin Woo Lee2, Hyun Gyu Lee, Jae-Hyuck Shim, Jeon Han Park, and Jae Myun Lee. Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway. Cell Communication and Signaling, In press, 2013.

  • Matthew B Greenblatt and Jae-Hyuck Shim. OsteoImmunology: A Brief Introduction. Immune Netw., 13(4):111-115, 2013.

  • Jae-Hyuck Shim*, Matthew B. Greenblatt, Weigou zou, Zhiwei Huang, Marc Wein, Nicholas Brady, Dorothy Hu, Jean Charron, heather Brodkin, Gregory Petsko, Dennis Zaller, Bo Zhai, Steven Gygi, Laurie H. Glimcher, Dallas Jones. Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.  J. Clin. Invest.,  123(9):4010-22, 2013. *(Co-corresponding authorship).

  • Matthew B. Greenblatt, Jae-Hyuck Shim*, Laurie H. Glimcher, Mitogen Activated Kinase Pathways in Osteoblasts. Ann. Rev. Cell Dev. Biol. In press, 2013. *(Co-first authorship).

  • Tae-Yoon Park, Seung-Hyung Kim, Yoon-Chul Shin, Nae-Hyun Lee, Christina Rae-Kyung Lee, Jae-Hyuck Shim, Laurie H. Glimcher, Inhee Mook-Jung, Eunji Cheong, Won-Ki Kim, and Jong-Soon Lim, and Sang-Kyou Lee. Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin. J. Control Release. 163:307-315, 2013.

2012

  • Marc N. Wein, Dallas C. Jones, Jae-Hyuck Shim, Antonios O. Aliprantis, Rosalyn Sulyanto, Vanja Lazarevic, Sandra L. Poliachik, Ted S. Gross, and Laurie H. Glimcher. Control of bone resorption in mice by Schnurri-3. Proc. Natl. Acad. Sci, USA. 109:8173-8178, 2012.
  • So Young Kim, Jae-Hyuck Shim, Eunyoung Chun, Ki-Young Lee. Reciprocal inhibition between transforming growth factor-b-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1), mitogen-activated kinase kinase kinases, and its suppression by the TAK1-binding protein 2 (TAB2), an adaptor protein for TAK1. J. Biol. Chem., 285:3381-3391, 2012.
  • Jae-Hyuck Shim*, Matthew B. Greenblatt, Anju Singh, Nicholas Brady, Dorothy Hu, Rebecca Drapp, Wataru Ogawa, Masato Kasuga, Tetsuo Noda, Sang-kyou Lee, Sang-hwa Yang, Vivienne I. Rebel, and Laurie H. Glimcher. Administration of recombinant BMP2/7 in utero reverses Rubinstein Taybi Syndrome-like skeletal defects induced by Pdk1 or Cbp mutations. J. Clin. Invest., 122:91-106, 2012 *(Co-corresponding authorship).

2011

  • Weiguo Zou, Matthew B. Greenblatt, Jae-Hyuck Shim, Shashi Kant, Bo Zhai, Sutada Lotinun, Nicholas Brady, Dorothy Hu, Steven P. Gygi, Roland Baron, Roger J. Davis, Dallas Jones, and Laurie H Glimcher. MLK3 regulates bone development downstream of the Faciogenital Dysplasia protein FGD1. J. Clin. Invest., 121:4383-4392, 2011.
  • Vanja Lazarevic, Xi Chen, Jae-Hyuck Shim, Eun-Sook Hwang, Alexandra N. Bolm, Mohamed Oukka, Ann-Hwee Lee, Vijay K. Kuchroo and Laurie H. Glimcher. T-bet represses TH17 differentiation through transcriptional blockade of the TH17 regulator RORgt. Nat. Immunol., 12:96-104, 2011.
  • Weiguo Zou, Xie Chen, Jae-Hyuck Shim, Zhiwei Huang, Nicholas Brady, Dorothy Hu, Rebecca Drapp, Kirsten Sigrist, Laurie H. Glimcher, and Dallas Jones. The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nat. Cell Biol., 13:59-65, 2011.

2010

  • Min-Jung Shin, Jae-Hyuck Shim, Jae-Young Lee, Wook-Jin Chae, Heung-Kyu Lee, Tomohiro Morio, Jun Han Park, Eun-Ju Chang, and Sang-Kyou Lee. Qualitative and quantitative differences in the intensity of Fas-mediated intracellular signals determine life and death in T cells. Int. J. Hematol., 92: 262-270, 2010.
  • Matthew B. Greenblatt, Jae-Hyuck Shim*, Weiguo Zou, Despina Sitara, Michelle Schweitzer, Dorothy Hu, Sutada Lotinun, Yasuyo Sano, Roland Baron, Jin Mo Park, Simon Arthur, Min Xie, Michael D. Schneider, Bo Zhai, Steven Gygi, Roger Davis, and Laurie H Glimcher. A MAPK pathway essential for bone homeostasis. J. Clin. Invest.120:2457-73, 2010. *(Co-first authorship)
  • Matthew B. Greenblatt, Jae-Hyuck Shim, and Laurie H. Glimcher. TAK1 mediates BMP signaling in cartilage. Ann. N.Y. Acad. Sci.1192: 385-390, 2010. 

2009

  • Jae-Hyuck Shim, Matthew B. Greenblatt, Min Xie, Michael D. Schneider, and Laurie H. Glimcher. TAK1 is an essential regulator of BMP signaling in cartilage. EMBO J., 28:2028-2041, 2009.

2008

  • So Yong Kim, Hee-Yeon Jo, Mi Hye Kim, Yun-yi Cha, Sung Won Choi, Jae-Hyuck Shim, Tae Jin Kim and Ki-Young Lee. H2O2-dependent hyperoxidation of peroxiredoxin 6 (Prdx6) plays a role in cellular toxicity via up-regulation of IPLA2 activity. J. Biol. Chem., 283: 33563-33568, 2008.
  • Heidi Mendoza, David G. Campbell, Kerry Burness, James Hastie, Natalia Ronkina, Jae-hyuck Shim, J. Simon C. Arthur, Roger J. Davis, Matthias Gaestel, Gary L. Johnson, Sankar Ghosh and Philip Cohen. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem. J., 409:711-722, 2008.

2006

  • Jae-Hyuck Shim, Changchun Xiao, Matthew S. Hayden, Ki-young Lee, E. Sergio Trombetta, Marc Pypaert, Atsuki Nara, Tamotsu Yoshimori, Bettina Wilm, Richard A. Flavell, Hediye Grdjument-Bromage, Paul Tempst, Brigid LM Hogan, Ira Mellman and Sankar Ghosh. CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. J. Cell Biol., 172:1045-56, 2006.

2005

  • Jae-Hyuck Shim, Changchun Xiao, Amber E. Paschal, Shannon T. Bailey, Ping Rao, Ki-Young Lee, Crystal Bussey, Matthew S. Hayden, Michael Steckel, Nobuyuki Tanaka, Gen Yamada, Kunihiro Matsumoto and Sankar Ghosh TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev., 19:2668-81, 2005.
  • Ki-Young Lee, Fulvio D'Acquisto, Matthew S. Hayden, Jae-hyuck Shim, and Sankar Ghosh. Protein Kinase PDK1 nucleates T Cell Receptor-Induced signaling complex for NF-kappaB activation. Science, 5718:114-118, 2005.

2004

  • Michael J. May, Signe E. Larsen, Jae-Hyuck Shim, Lisa A. Madge and Sankar Ghosh. A novel ubiquitin-like domain in IkB-kinase b is required for functional activity of the kinase. J. Biol. Chem., 279:45528-39, 2004.

2003

  • Changchun Xiao, Jae-Hyuck Shim, Michael Kluppel, Samuel Shao-Min Zhang, Chen Dong, Richard A. Flavell, Xin-Yuan Fu, Jeffrey L. Wrana, Brigid L.M. Hogan and Sankar Ghosh Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev., 17:2933-49, 2003.

2002

  • Jae-Hyuck Shim, Heung-Kyu Lee, Eun-Ju Chang, Wook-Jin Chae, Jin-Hwan Han, Duck-Jong Han, Tomohiro Morio, Jung-Jin Yang, Alfred Bothwell and Sang-Kyou Lee. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc. Natl. Acad. Sci, USA. 99:10617-22, 2002.

1998

  • Jae-Hyuck Shim, Hyung-Jung Kim, Jung-Hee Lim, Sang-Kyou Lee. Functions of Ich-1L and Ich-1S in Apoptotic Signaling of Jurkat T cells. Kor. J. Immunol., 20:91-99, 1998.
  • Jae-young, Lee, Jae-Hyuck Shim, Jung-Hee Lim, Yong-Sub Song, Sang-Kyou Lee. Supplement of Incomplete Apoptosis Through CD8/Fas Chimeric Molecule By PMA or IFN-g. Kor. J. Immunol., 20:203-209, 1998.

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